The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 04, 2023
Filed:
Sep. 22, 2020
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Université Toulouse Iii—paul Sabatier, Toulouse, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Nathalie Vergnolle, Toulouse, FR;
Corinne Rolland, Toulouse, FR;
Céline Deraison-Manuel, Toulouse, FR;
Instutut Nationale de la Santé et de la Recherche Médicale, Paris, FR;
Université Toulouse III—Paul Sabatier, Toulouse, FR;
Centre Nationale de la Recherche Scientifique (CNRS), Paris, FR;
Abstract
The invention is in the field of therapy of gut inflammatory diseases such as Inflammatory Bowel Diseases (IBD) or Irritable Bowel Syndrome (IBS) including Gluten hypersensitivity. The inventors showed that ELA2A secreted by epithelial cells in the extracellular space is over-expressed in IBD conditions degrading tight junction proteins and controlling cytokines expression. Overexpression of ELA2A conferred a pro-inflammatory phenotype both in cell expression systems and in vivo in animal model of IBD. The inventors also showed that ELA2 over-expressing intestinal epithelial cells increase the release of CXCL8 protein compared to control cells. The increased CXCL-8 protein release observed in cells overexpressing ELA2A is inhibited by ELAFIN addition to the culture, in a dose-dependent manner. In particular, the invention relates to inhibitors of Elastase ELA2A, for use in the treatment of Inflammatory Bowel Diseases, such as Crohn's Disease, Ulcerative Colitis, Celiac disease, and Pouchitis.