Company Filing History:
2 out of 157 
2 out of 5,099 
1 out of 1 
Years Active: 2020-2023
Title: Corinne Rolland: Innovator in Gut Inflammatory Disease Therapies
Introduction
Corinne Rolland is a notable inventor based in Toulouse, France. She has made significant contributions to the field of therapy for gut inflammatory diseases. With a focus on innovative treatments, she has been awarded 2 patents for her groundbreaking work.
Latest Patents
Corinne Rolland's latest patents include a method of treating inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), or gluten hypersensitivity by administering an elastase 2A (ELA2A) inhibitor. This invention addresses the therapy of gut inflammatory diseases such as IBD and IBS. The research indicates that ELA2A, secreted by epithelial cells, is over-expressed in IBD conditions, leading to the degradation of tight junction proteins and the regulation of cytokine expression. The overexpression of ELA2A results in a pro-inflammatory phenotype, both in cell expression systems and in vivo animal models of IBD. Furthermore, the study shows that intestinal epithelial cells overexpressing ELA2A increase the release of CXCL8 protein compared to control cells. The increased release of CXCL-8 protein is inhibited by ELAFIN in a dose-dependent manner. This invention particularly relates to inhibitors of Elastase ELA2A for the treatment of various inflammatory bowel diseases, including Crohn's Disease, Ulcerative Colitis, Celiac disease, and Pouchitis.
Career Highlights
Corinne Rolland has worked with esteemed institutions such as Université Toulouse III – Paul Sabatier and the Centre National de la Recherche Scientifique. Her work has significantly advanced the understanding and treatment of gut inflammatory diseases.
Collaborations
Some of her notable coworkers include Nathalie Vergnolle and Céline Deraison-Manuel, who have contributed to her research endeavors.
Conclusion
Corinne Rolland's innovative work in the field of gut inflammatory diseases showcases her dedication to improving therapeutic options for patients. Her patents reflect a commitment to advancing medical science and enhancing patient care.