Company Filing History:
Years Active: 2010-2019
Title: Innovations by Inventor Natalia N Singh in Spinal Muscular Atrophy Treatments
Introduction
Natalia N Singh is a prominent inventor based in Shrewsbury, MA, known for her contributions to the field of genetic therapies. With a total of five patents to her name, she has significantly impacted the research and treatment landscape for spinal muscular atrophy (SMA). Her innovative approach centers around enhancing the expression of essential proteins necessary for motor neuron function, providing hope for countless individuals affected by this debilitating condition.
Latest Patents
One of Natalia N Singh's latest patents addresses spinal muscular atrophy treatment through the targeting of SMN2 splice site inhibitory sequences. This invention focuses on methods and compositions that can effectively block the inhibitory effects of a recently identified intronic sequence named ISS-N1, located within the SMN2 gene. The invention includes oligonucleotide reagents, specifically oligoribonucleotides, which target the ISS-N1 site in the SMN2 pre-mRNA. By modulating the splicing of SMN2 pre-mRNA to include exon 7 in the processed transcript, her approach results in elevated expression of the SMN protein. This compensatory mechanism is crucial for offsetting the typical reduction of SMN protein in individuals suffering from SMA.
Career Highlights
Natalia N Singh’s career is marked by her dedication to advancing genetic research and developing impactful therapies. Her association with the University of Massachusetts, where she conducts her research, has allowed her to collaborate with leading scientists in the field. Singh's innovative work has the potential to change the way SMA is treated, showcasing her commitment to research and development in genetic therapies.
Collaborations
Throughout her career, Natalia has had the privilege of working alongside esteemed colleagues, including Ravindra N Singh and Nirmal K Singh. These collaborations amplify the impact of her research, as they combine expertise from various domains within biomedical sciences to drive innovation in SMA treatment.
Conclusion
In conclusion, inventor Natalia N Singh exemplifies the spirit of innovation in addressing the challenges associated with spinal muscular atrophy. Her recent patents reflect a significant step forward in the development of effective therapies aimed at enhancing SMN protein expression. With her ongoing work at the University of Massachusetts and collaborative efforts with respected peers, she continues to pave the way for breakthroughs that could change lives.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.