Location History:
- Boulder, CO (US) (1997 - 2006)
- Boston, MA (US) (1997 - 2006)
- Lafayette, CO (US) (1998 - 2014)
Company Filing History:
24 out of 110 
4 out of 138 
3 out of 7 
Years Active: 1997-2014
Title: The Innovative Contributions of Nassim Usman in the Field of Gene Expression Modulation
Introduction: Nassim Usman is a prominent inventor based in Boulder, Colorado, renowned for his significant contributions to the field of molecular biology and gene expression modulation. With an impressive portfolio of 32 patents, Usman has made remarkable advancements in therapeutic applications using nucleic acid technology.
Latest Patents: Among his latest innovations are two notable patents. The first patent is on "RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)." This invention focuses on methods and reagents to modulate gene expression for therapeutic, diagnostic, and genomic discovery applications. It emphasizes the use of chemically modified small nucleic acid molecules capable of mediating RNA interference (RNAi) against target sequences, which can potentially treat various diseases by influencing gene activity.
The second recent patent involves "Nucleozymes," which are nucleic acid molecules containing ribonucleotides and deoxyribonucleotides or their analogues. These nucleozymes exhibit catalytic activity and offer greater resistance to degradation compared to traditional ribozymes. The patent outlines methods for preparing nucleozymes and their potential uses as therapeutic agents.
Career Highlights: Nassim Usman has had a distinguished career working with leading biotechnology firms. He was associated with Ribozyme Pharmaceuticals and Sirna Therapeutics, where he contributed to pioneering research in nucleic acid technologies. His expertise and innovative mindset have earned him recognition as a key figure in the industry.
Collaborations: Throughout his career, Usman has collaborated with talented individuals such as Leonid Beigelman and Francine E. Wincott. Their combined efforts in research and development have significantly impacted the scientific community and the progress of nucleic acid-based therapies.
Conclusion: Nassim Usman's innovative work continues to shape the fields of gene therapy and molecular biology. With a robust portfolio of patents and valuable collaborations, his contributions are paving the way for new therapeutic strategies that harness the power of nucleic acids. As advancements in this area continue, Usman's inventions will likely play a crucial role in addressing various genetic diseases and conditions.