Company Filing History:
Years Active: 1996-1998
Title: Nandkumar Bhongle: Innovator in Nucleotide Synthesis
Introduction
Nandkumar Bhongle is a notable inventor based in Shrewsbury, MA (US). He has made significant contributions to the field of nucleotide synthesis, holding a total of 3 patents. His innovative methods have advanced the techniques used in the synthesis of mono- and oligonucleotides.
Latest Patents
Nandkumar Bhongle's latest patents include groundbreaking methods for H-phosphonate synthesis of mono- and oligonucleotides. One of his patents discloses new methods for synthesizing mono- and oligonucleotide H-phosphonates by contacting a mononucleoside with phosphonic acid and benzoyl anhydride. This process yields the corresponding mononucleoside H-phosphonate, preferably using a catalytic amount of triphosgene. Another patent focuses on synthesizing oligonucleotides using triphosgene, where a mononucleoside is contacted with phosphorous acid to produce the corresponding H-phosphonate. This method also allows for the coupling of mononucleosides and oligonucleotides, enhancing the efficiency of nucleotide synthesis.
Career Highlights
Nandkumar Bhongle is currently associated with Hybridon, Inc., where he continues to innovate in the field of nucleotide chemistry. His work has been instrumental in developing new methodologies that improve the synthesis processes, making them more efficient and effective.
Collaborations
Nandkumar has collaborated with Jin-Yan Tang, contributing to advancements in their shared field of research. Their partnership has fostered innovative solutions and methodologies in nucleotide synthesis.
Conclusion
Nandkumar Bhongle's contributions to the field of nucleotide synthesis through his patents and collaborations highlight his role as a significant innovator. His work continues to influence the development of new techniques in this vital area of research.