Nancy J Casna

Title: Nancy J Casna: Innovator in DNA Purification Techniques

Introduction

Nancy J Casna is a notable inventor based in Hopewell Junction, NY (US). She has made significant contributions to the field of molecular biology, particularly in the area of DNA purification. Her innovative methods have the potential to advance genetic research and diagnostics.

Latest Patents

Nancy J Casna holds a patent for a method titled "Method for locating and purifying DNA containing single base mismatches." This patent describes a technique for distinguishing DNA fragments that contain single base mismatches from their perfectly paired counterparts. The method involves modifying single-stranded regions within a duplex fragment with carbodiimide, which selectively reacts with unpaired guanine (G) and thymine (T) residues in DNA. This allows for the clear distinction between modified and unmodified DNA fragments when fractionated on high percentage polyacrylamide gels. The application of this technique is crucial for locating and purifying DNA sequence differences that are responsible for phenotype variation and inherited diseases.

Career Highlights

Throughout her career, Nancy has demonstrated a commitment to advancing scientific knowledge and technology. Her work at Lifecodes Corporation has positioned her as a leader in the field of genetic research. She has been instrumental in developing methods that enhance the understanding of genetic variations and their implications in health and disease.

Collaborations

Nancy has collaborated with esteemed colleagues, including John P Ford and David F Novack. These partnerships have fostered an environment of innovation and have contributed to the success of her research endeavors.

Conclusion

Nancy J Casna's contributions to DNA purification techniques exemplify her dedication to scientific advancement. Her innovative methods have the potential to significantly impact genetic research and diagnostics.