This inventor holds 3 USPTO granted patents. Top assignees: Dartmouth College, University of Massachusetts. Active years: 1997-2009.
Company Filing History:
3 out of 701 
3 out of 1,623 
Years Active: 1997-2009
Title: Innovations by Nancy E Phillips
Introduction
Nancy E Phillips is a notable inventor based in Shrewsbury, MA (US). She has made significant contributions to the field of immunology, particularly in the area of T-cell tolerance and transplantation. With a total of 3 patents, her work has the potential to impact various medical treatments and transplant procedures.
Latest Patents
One of her latest patents involves methods of inducing T-cell non-responsiveness with anti-gp39 24-31 antibodies. This patent discloses methods for inducing T cell tolerance to a tissue or organ graft in a transplant recipient. The methods include administering an allogeneic or xenogeneic cell that expresses donor antigens and has a ligand on its surface that interacts with a receptor on the recipient T cell. Additionally, an antagonist of the receptor is administered to inhibit the interaction of the ligand with the receptor. A preferred embodiment involves using a resting B cell as the allogeneic or xenogeneic cell, with gp39 as the molecule mediating contact-dependent helper effector function. The methods can be applied to induce T cell tolerance to various transplants, including liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach, and intestine. Furthermore, a method for treating diabetes is also disclosed, which involves administering allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist, and pancreatic islets.
Career Highlights
Throughout her career, Nancy has worked with prestigious institutions such as Dartmouth College and the University of Massachusetts. Her research has focused on advancing the understanding of immune responses and improving transplant outcomes.
Collaborations
Some of her notable coworkers include Randolph J Noelle and Fiona H Durie, who have contributed to her research endeavors.
Conclusion
Nancy E Phillips is a pioneering inventor whose work in immunology and transplantation has the potential to transform medical practices. Her innovative methods for inducing T-cell tolerance are crucial for improving transplant success rates and treating conditions like diabetes.