Location History:
- Neuss, DE (2012 - 2021)
- Hilden, DE (2013 - 2022)
Company Filing History:
Years Active: 2012-2022
Title: Innovations by Inventor Nan Fang
Introduction
Nan Fang is a prominent inventor based in Hilden, Germany. He has made significant contributions to the field of molecular biology, particularly in the development of RNA sequencing technologies. With a total of 11 patents to his name, his work has advanced the understanding of RNA and its various applications.
Latest Patents
Among his latest patents, Nan Fang has developed a "Method for generating a RNA-sequencing library." This invention refers to a novel method of preparing strand-specific RNA-sequencing libraries that can be used to identify DNA coding and non-coding strands that are transcribed to RNA. Such strand-specific RNA-sequencing libraries are especially useful in discovering anti-sense RNA and non-coding RNA. The method utilizes random primer oligonucleotides, covalently coupled to a moiety that blocks ligation, for the reverse transcription reaction or the subsequent generation of the second DNA strand. This ensures that only one strand of the generated double-stranded DNA is ligated to sequencing adapters at the 5' nucleotide and sequenced by paired-end sequencing.
Another significant patent is the "Method for generating a stranded RNA library." This invention relates to a method for preparing a strand-specific library from a nucleic acid or preferably RNA sample. The process includes several steps: optionally fragmenting the RNA sample, generating a plurality of first cDNA strands through reverse transcription, generating a plurality of second cDNA strands using a DNA polymerase, and ligating adapters to the 3' and 5' termini of the double-stranded cDNA. The invention also includes a kit for preparing a strand-specific library from an RNA sample.
Career Highlights
Nan Fang is currently employed at Qiagen GmbH, a leading company in the field of molecular diagnostics and life sciences. His work at Qiagen has allowed him to collaborate with other experts in the field and contribute to groundbreaking research.
Collaborations
Some of his notable coworkers include Andreas Missel and Katja Heitz, who have also played significant roles in advancing the research and development efforts at Qiagen.
Conclusion
Nan Fang's innovative contributions to RNA sequencing technologies have positioned him as a key figure in molecular biology. His patents reflect a commitment to advancing scientific knowledge and improving methodologies in the field.
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