Nagasuma Chandra

Title: Nagasuma Chandra: Innovator in Glioma Therapy

Introduction

Nagasuma Chandra is a prominent inventor based in Bengaluru, India. She has made significant contributions to the field of cancer therapy, particularly in glioma treatment. With a total of 3 patents, her work focuses on innovative approaches to combat glioblastoma.

Latest Patents

One of her latest patents is centered around a Nicotinamide phosphoribosyltransferase (NMPRTase) inhibitor for glioma therapy. This invention involves the identification of a compound that inhibits the enzyme NMPRTase, which is crucial for glioma cancer cell growth. The patent details a structure-based drug discovery approach aimed at developing novel inhibitors for glioblastoma therapy. The research highlights the virtual screening of 13,000 compounds, resulting in the identification of 34 potential ligands. Among these, two compounds showed significant efficacy in inhibiting the conversion of nicotinamide to NAD, with one compound effectively inhibiting the growth of a PBEF1 overexpressing glioma-derived cell line, U87.

Career Highlights

Nagasuma Chandra has worked with notable organizations such as Infosys Limited and the Indian Institute of Science. Her experience in these institutions has contributed to her expertise in the field of cancer research and drug development.

Collaborations

Some of her coworkers include Anirban Ghosh and Somasundaram Kumaravel, who have collaborated with her on various projects related to her research.

Conclusion

Nagasuma Chandra's innovative work in glioma therapy showcases her dedication to advancing cancer treatment through her patented inventions. Her contributions are paving the way for new therapeutic options in the fight against glioblastoma.