Location History:
- Columbus, OH (US) (2013)
- Los Angeles, CA (US) (2016)
Company Filing History:
Years Active: 2013-2016
Title: The Innovative Contributions of Muller Fabbri
Introduction
Muller Fabbri is a notable inventor based in Los Angeles, California. He has made significant contributions to the field of cancer research through his innovative patents. With a total of two patents, Fabbri's work focuses on the mechanisms of tumor growth and metastasis.
Latest Patents
Fabbri's latest patents include methods and compositions related to miR-21 and miR-29a, exosome inhibition, and cancer metastasis. This invention provides materials and methods that reveal how tumor-secreted miR-21 and miR-29 can bind to receptors of the Toll-like receptor family, specifically murine TLR7 and human TLR8, in immune cells. This binding triggers a TLR-mediated prometastatic inflammatory response, which ultimately leads to tumor growth and metastasis. By acting as paracrine agonists of TLRs, secreted miRNAs play a crucial role in regulating the tumor microenvironment. This mechanism is vital for understanding tumor-immune system communication, tumor growth, and potential cancer treatments. Another significant patent involves methods for reverting methylation by targeting methyltransferases. This patent discloses methods for restoring a desired pattern of DNA methylation, which can induce the re-expression of methylation-silenced tumor suppressor genes and inhibit tumorigenicity both in vitro and in vivo.
Career Highlights
Throughout his career, Muller Fabbri has worked with esteemed institutions such as The Ohio State University and the Ohio State Innovation Foundation. His research has contributed to advancements in understanding cancer biology and therapeutic strategies.
Collaborations
Fabbri has collaborated with notable figures in the field, including Carlo M. Croce, enhancing the impact of his research through shared expertise and knowledge.
Conclusion
Muller Fabbri's innovative work in cancer research through his patents highlights the importance of understanding tumor biology and developing effective treatments. His contributions continue to influence the field and pave the way for future advancements.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.