Motohiro Fuke

Title: Motohiro Fuke: Innovator in Yeast Biotechnology

Introduction

Motohiro Fuke is a notable inventor based in Tulsa, OK (US), recognized for his contributions to yeast biotechnology. He holds 2 patents that focus on the production of human tumor necrosis factor and the transformation of yeast strains.

Latest Patents

Fuke's latest patents include innovative methods for yeast production of human tumor necrosis factor. These patents disclose novel DNA constructs that comprise yeast regulatory regions along with the structural coding region for human tumor necrosis factor. The constructs are incorporated into various linear and circular plasmids, which are utilized for yeast transformation, ultimately leading to the production of human tumor necrosis factor by yeast. Another significant patent involves carbon and energy source markers for the transformation of yeast strains. This invention requires transforming yeast with DNA fragments that encode a gene function absent in the wild-type strains. The process includes regenerating transformants on a non-selective medium and selecting colonies capable of growth on a specific carbon and energy source, thus allowing for positive selection of transformed strains.

Career Highlights

Throughout his career, Fuke has worked with prominent companies such as Phillips Petroleum Company and Research Corporation Technologies, Inc. His work has significantly advanced the field of biotechnology, particularly in yeast transformation and protein production.

Collaborations

Fuke has collaborated with notable individuals in his field, including Kotikanyadan Sreekrishna and Rica H Potenz. These collaborations have contributed to the development of his innovative patents and research.

Conclusion

Motohiro Fuke's work in yeast biotechnology has led to significant advancements in the production of human tumor necrosis factor and yeast transformation techniques. His contributions continue to impact the field positively.