Moshe Shani

Title: Moshe Shani: Innovator in Human Serum Albumin Expression Constructs

Introduction

Moshe Shani is a notable inventor based in Mobile Post Modyin, IL. He has made significant contributions to the field of biotechnology, particularly in the development of DNA constructs for human serum albumin expression.

Latest Patents

Shani holds a patent for a "Human serum albumin expression construct." This invention provides DNA constructs that include a promoter DNA sequence and a DNA sequence coding for human serum albumin. In one embodiment, the human serum albumin sequence comprises at least one, but not all, of the introns in the naturally occurring gene encoding for the HSA protein. Additionally, the DNA constructs may include a 5' regulatory sequence that directs the expression and secretion of HSA protein in the milk of a transgenic animal. Preferably, the promoter gene is a milk protein promoter sequence such as β-lactoglobulin. The invention also encompasses transgenic animals that secrete HSA in the milk of lactating females, as well as vectors comprising the constructs.

Career Highlights

Throughout his career, Moshe Shani has worked with prominent companies in the pharmaceutical and biotechnology sectors. Notable among these are Rhone-Poulenc Rorer Pharmaceuticals Inc. and Peri Development Applications (1985) Ltd. His work has significantly advanced the understanding and application of human serum albumin in medical and research settings.

Collaborations

Shani has collaborated with esteemed colleagues, including David R. Hurwitz and Margret Nathan. These partnerships have contributed to the successful development and implementation of his innovative ideas.

Conclusion

Moshe Shani's contributions to the field of biotechnology, particularly through his patent on human serum albumin expression constructs, highlight his role as an influential inventor. His work continues to impact the medical and research communities positively.