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1 out of 1 Years Active: 1989-1997
Title: Monika Mergler: Innovator in Peptide Chemistry
Introduction
Monika Mergler is a distinguished inventor based in Liestal, Switzerland. She has made significant contributions to the field of peptide chemistry, holding a total of 3 patents. Her work focuses on the development of novel peptide derivatives and synthesis methods that enhance the efficacy and purity of peptide-based products.
Latest Patents
Monika's latest patents include innovative advancements in peptide derivatives. One of her notable inventions provides a sugar derivative of a biologically active peptide. This derivative has a prolonged duration of action compared to the non-sugar modified peptide. It contains at least one amino acid unit with a sugar residue attached to an amino group through a coupling other than a direct N-glycosidic bond. Additionally, it can be a condensation product of a carboxyl group containing sugar and a peptide with fewer than 8 amino acid units, coupled in a manner other than a direct amide bond.
Another significant patent involves a resin-linker combination for the solid-phase synthesis of peptides. This invention relates to a novel polymeric carrier and a process for its production. The process includes reacting chloromethylated polystyrene, cross-linked with divinylbenzene, with a 4-hydroxy-2-substituted-benzyl alcohol. It allows for the attachment of α-amino acids with amino and side-chain protection to the carrier, facilitating the synthesis of peptides under extremely mild acidic conditions, resulting in high purity and yield.
Career Highlights
Monika has worked with prominent companies in the pharmaceutical and chemical industries, including Sandoz GmbH and Bachem Feinchemikalien AG. Her expertise in peptide synthesis and modification has positioned her as a key player in her field.
Collaborations
Throughout her career, Monika has collaborated with esteemed colleagues such as Jacques Gosteli and Peter Grogg. These partnerships have further enriched her research and development efforts in peptide chemistry.
Conclusion
Monika Mergler's innovative work in peptide chemistry has led to significant advancements in the field, showcasing her expertise and dedication to scientific progress. Her contributions continue to influence the development of peptide-based therapies and applications.