Monika Knopp

Title: Monika Knopp: Innovator in Retinoic Acid Production

Introduction

Monika Knopp is a distinguished inventor based in Rheinfelden, Switzerland. She has made significant contributions to the field of chemistry, particularly in the production of retinoic acid, which has important applications in medicine and biochemistry. Her innovative methods have garnered attention in the scientific community.

Latest Patents

Monika Knopp holds a patent for a method of production of 9-cis-retinoic acid. This improved method involves a reaction between a β-formyl-crotonic acid C-Calkyl or phenyl ester and an isolated 9-(Z)-C-triarylphosphonium salt through the Wittig reaction in the presence of a base. The process results in the corresponding 9-(Z)-retinoic acid ester, which is then saponified with a base to yield the 9-(Z)-retinoic acid carboxylate. Following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained. Additionally, her method includes improvements for the enrichment and isolation of the 9-(Z)-C-triarylphosphonium salt.

Career Highlights

Monika Knopp is currently associated with DSM IP Assets B.V., where she continues to advance her research and development efforts. Her work has not only contributed to her company but has also had a broader impact on the field of organic chemistry.

Collaborations

Monika collaborates with notable colleagues, including Michael Stanek and Stefan Essl. Their combined expertise enhances the innovative environment in which they work.

Conclusion

Monika Knopp is a remarkable inventor whose work in the production of retinoic acid exemplifies the intersection of innovation and practical application in chemistry. Her contributions continue to influence the scientific community and pave the way for future advancements.