Company Filing History:
Years Active: 1994
Title: Moneesh Chatterjee: Innovator in Nucleic Acid Research
Introduction
Moneesh Chatterjee is a notable inventor based in Stony Brook, NY (US). He has made significant contributions to the field of nucleic acid research, particularly through his innovative patent. His work focuses on the development of reagents that enhance the functionality of oligonucleotides.
Latest Patents
Moneesh Chatterjee holds a patent for "Nucleic acids labeled with naphthoquinone probe." This invention involves constructing a sequence-directed reagent by conjugating a methyl naphthoquinone derivative to a hexamethylamino linker attached to the 5' terminus of an oligonucleotide. The process allows for target modification following photochemical activation, resulting in a covalent crosslink between the reagent and target strands. This modification is resistant to acid, base, or reductants, effectively blocking the exonuclease activity of the Klenow fragment of DNA polymerase I. Additionally, the patent describes an embodiment where a highly reactive moiety, such as Br, is attached to the methyl group of the naphthoquinone derivative, enhancing the reagent's functionality.
Career Highlights
Moneesh Chatterjee is affiliated with the State University of New York, where he continues to advance his research in nucleic acids. His innovative approach has garnered attention in the scientific community, contributing to the understanding of DNA interactions and modifications.
Collaborations
Moneesh has collaborated with Steven E Rokita, further enhancing the research output and innovation in their field.
Conclusion
Moneesh Chatterjee's work in nucleic acid research exemplifies the impact of innovative thinking in science. His patent on naphthoquinone-labeled nucleic acids represents a significant advancement in the field, showcasing his dedication to enhancing molecular biology techniques.