Mohanathasan Chelladurai

Title: Innovations by Mohanathasan Chelladurai

Introduction

Mohanathasan Chelladurai is an accomplished inventor based in Southfield, MI (US). He has made significant contributions to the field of medical research, particularly in understanding blood coagulation and cancer metastasis. With a total of two patents to his name, his work has the potential to impact clinical practices significantly.

Latest Patents

Chelladurai's latest patents include a method for measuring blood procoagulant activity of human leukocytes. This invention addresses thromboembolic complications that are often seen in cancer patients and organ transplant recipients. His research isolated two proteins with procoagulant activity from human ovarian carcinoma extracts, revealing important insights into tumor metastases. The amino terminal sequence of one of these proteins was found to have 100% homology to the major histocompatibility antigen HLA-DR. This discovery could lead to advancements in understanding how procoagulants influence thrombin generation in normal plasma.

Another significant patent is a method for testing the presence of metastatic tumor cells based on Human Leukocyte Antigen (HLA). This method utilizes a protein that selectively binds to HLA to identify excess HLA, which is characteristic of tumor cells. The preferred protein for this test is the enterotoxin A (SEA) produced by Staphylococcus aureus, showcasing innovative approaches to cancer diagnostics.

Career Highlights

Chelladurai is currently associated with Biomide Investment Limited Partnership, where he continues to develop his research and innovations. His work is pivotal in bridging the gap between laboratory research and clinical applications, particularly in oncology and hematology.

Collaborations

Some of his notable coworkers include Kenneth V Honn and Daniel A Walz, who have collaborated with him on various research projects. Their combined expertise enhances the quality and impact of their work in the medical field.

Conclusion

Mohanathasan Chelladurai's contributions to medical research through his patents reflect his dedication to advancing healthcare solutions. His innovative methods for measuring blood procoagulant activity and testing for metastatic tumor cells hold promise for improving patient outcomes.