Company Filing History:
Years Active: 1990
Title: Innovations of Mohamed K Ruyan
Introduction
Mohamed K Ruyan is an accomplished inventor based in Ann Arbor, MI (US). He has made significant contributions to the field of medical imaging through his innovative work on cholesterol analogues. His research focuses on developing novel compounds that can enhance imaging techniques for adrenal glands.
Latest Patents
Ruyan holds a patent for "Radioiodinated arylaliphatic ether analogues of cholesterol." This patent describes novel radioiodinated analogues of naturally occurring cholesterol esters, specifically arylaliphatic cholesteryl ethers. These compounds are selective for low-density lipoproteins and have been shown to be effective imaging agents for adrenal glands. The arylaliphatic cholesteryl ethers have a general formula where X represents a radioactive isotope of iodine, and n is an integer between 1 and 20. Two illustrative examples include m-iodobenzyl cholesteryl ether and 12-(m-iodophenyl) dodecyl cholesteryl ether, which were radiolabeled with 125I through an isotope exchange reaction. Tissue distribution studies indicate significant accumulation of these cholesteryl ethers in the adrenal glands and, to a lesser extent, in the liver. The cholesteryl ethers selectively incorporate into plasma lipoproteins, as determined by polyacrylamide gel electrophoresis.
Career Highlights
Ruyan is affiliated with the University of Michigan, where he continues to advance his research in the field of medical imaging. His work has garnered attention for its potential applications in improving diagnostic techniques.
Collaborations
Some of Ruyan's notable coworkers include Raymond E Counsell and Susan W Schwendner. Their collaborative efforts contribute to the ongoing research and development of innovative imaging agents.
Conclusion
Mohamed K Ruyan's contributions to the field of medical imaging through his patented innovations highlight the importance of research in enhancing diagnostic capabilities. His work continues to pave the way for advancements in imaging technology.