Location History:
- Meylan, FR (2006 - 2008)
- Strasbourg, FR (2012 - 2021)
Company Filing History:
5 out of 5,089 
4 out of 170 
3 out of 639 
Years Active: 2006-2021
Title: **Innovator Mitsuharu Kotera: Pioneering Advances in RNA Interference**
Introduction
Mitsuharu Kotera, based in Strasbourg, France, is a distinguished inventor recognized for his significant contributions to the field of RNA technology. With a total of six patents to his name, he has been at the forefront of developing innovative solutions that enhance the efficacy of RNA interference.
Latest Patents
Kotera's recent patents showcase his groundbreaking work, particularly in the area of cationic small interfering RNAs (siRNAs). His patent titled "Cationic siRNAs, synthesis and use for RNA interference" emphasizes the design of double-stranded RNA fragments that have oligocations grafted to their ends. These fragments are characterized by a balance of cationic and anionic charges, providing a mechanism that enhances their biomedical applications.
Another notable patent, "Cationic oligonucleotides, automated methods for preparing same and their uses," details innovative methodologies for synthesizing oligonucleotide-oligocation molecules. This invention takes advantage of automated phosphoramidite chemistry to create custom oligonucleotides with diverse chemical modifications, which are essential for enhancing the stability and efficacy of therapeutic agents.
Career Highlights
Throughout his career, Kotera has held key positions in prestigious institutions. He has worked extensively at the Centre National De La Recherche Scientifique (CNRS) and the Université de Strasbourg, both of which are renowned for their research contributions in the scientific community. His work has not only advanced the understanding of RNA interference but has also laid the groundwork for future innovations in genetic research.
Collaborations
Mitsuharu Kotera has collaborated with esteemed colleagues such as Ali Laayoun and Jean-Serge Remy. These partnerships have fostered a collaborative atmosphere that encourages the sharing of ideas and expertise, further driving innovation in their respective fields.
Conclusion
Mitsuharu Kotera’s contributions to the field of RNA technology are invaluable, marked by his six patents that reflect a commitment to advancing scientific understanding and practical applications. His innovative approaches in synthesis and application of cationic siRNAs signify his pivotal role as an inventor. As research continues to evolve, Kotera's work will undoubtedly influence future developments in RNA research and therapeutic interventions.