Mingyi Xie

Title: The Innovative Contributions of Mingyi Xie

Introduction

Mingyi Xie is a notable inventor based in Gainesville, FL (US). He has made significant contributions to the field of molecular biology, particularly in the area of RNA interference. His innovative work has implications for disease treatment and detection.

Latest Patents

Mingyi Xie holds a patent for "miRNA switches for RNA-triggered control of RNA interference." This patent describes methods, compositions, and systems that utilize synthetic nucleic acid molecules to enable inducible or conditional pri-miRNA processing in mammalian cells in vivo. The technology involves Orthogonal RNA Interference induced by Trigger RNA (ORIENTR), which can switch between inactive and active forms upon interaction with specific RNA-trigger molecules. This interaction facilitates the formation of a correctly folded pri-miRNA scaffold substrate, leading to RNAi-mediated repression of target genes. The methods outlined in the patent also include applications for disease treatment and the detection of target RNA in biological samples.

Career Highlights

Mingyi Xie has worked with prestigious institutions such as Boston University and the University of Florida Research Foundation. His experience in these organizations has contributed to his expertise in RNA technology and molecular biology.

Collaborations

Mingyi Xie has collaborated with notable colleagues, including Alexander A Green and Yu Zhou. Their combined efforts have further advanced research in the field of RNA interference.

Conclusion

Mingyi Xie's innovative work in RNA technology and his contributions to the field of molecular biology highlight his role as a significant inventor. His patent on miRNA switches demonstrates the potential for advancements in disease treatment and detection.