Company Filing History:
Years Active: 2025
Title: Innovations of Mingjiang Chen in E3 Ligase Technology
Introduction
Mingjiang Chen is a notable inventor based in Beijing, China. He has made significant contributions to the field of genetics and developmental biology. His work focuses on the preparation of multisubunit SCF E3 ligases, which are crucial for various biological processes.
Latest Patents
Mingjiang Chen holds a patent titled "Method for preparing multisubunit SCF E3 ligase with fusion protein through in vitro reconstitution, and use of multisubunit SCF E3 ligase." This patent discloses a method for preparing a multisubunit SCF E3 ligase using an engineered SKP1-Cullin1-RBX1 fusion protein, referred to as eSCR. The method involves a reaction with an F-box protein to obtain the multisubunit SCF E3 ligase. Experimental results indicate that different multisubunit SCF E3 ligases can be successfully prepared with the eSCR fusion protein, demonstrating biological activity.
Career Highlights
Mingjiang Chen is affiliated with the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences. His research has contributed to advancements in understanding the mechanisms of E3 ligases and their applications in biotechnology.
Collaborations
Mingjiang Chen has collaborated with notable colleagues, including Jiayang Li and Bing Wang. Their joint efforts have furthered research in the field of developmental biology.
Conclusion
Mingjiang Chen's innovative work in the preparation of multisubunit SCF E3 ligases showcases his expertise and contributions to the scientific community. His patent reflects a significant advancement in the understanding and application of E3 ligases in biological research.