Ming-I Chang

Title: The Innovations of Ming-I Chang

Introduction

Ming-I Chang is a notable inventor based in Taipei, Taiwan. He has made significant contributions to the field of biotechnology, particularly in the development of bispecific antibodies. His work has implications for enhancing T-cell activation, which is crucial for various therapeutic applications.

Latest Patents

Ming-I Chang holds a patent for a bispecific T-cell activator antibody. This invention relates to bispecific antibodies that utilize combinations of linker and hinge sequences to create linker-hinge interface domains with biological significance. These domains covalently join two molecules, preserving their biological activities, stabilizing their characteristics, and modulating their properties. The specific sequences required for functionality include linker (GGGGS) and hinge (CPPCP) sequences, which are essential for maintaining T-lymphocyte mediated activity.

Career Highlights

Throughout his career, Ming-I Chang has worked with various organizations, including the Development Center for Biotechnology and DCB-USA LLC. His experience in these institutions has allowed him to advance his research and contribute to the field of biotechnology significantly.

Collaborations

Ming-I Chang has collaborated with notable colleagues such as Yu-Shen Hsu and Show-Shan Sheu. These partnerships have facilitated the exchange of ideas and expertise, further enhancing the impact of his work.

Conclusion

Ming-I Chang's innovative contributions to biotechnology, particularly through his patent on bispecific T-cell activator antibodies, highlight his role as a significant inventor in the field. His work continues to influence advancements in therapeutic applications.