Mike A Clark

Title: Mike A Clark: Innovator in Solubilization and Diagnosis

Introduction

Mike A Clark is a notable inventor based in Denville, NJ (US). He has made significant contributions to the fields of solubilization and medical diagnostics. With a total of 6 patents, his work has had a profound impact on various applications, particularly in the pharmaceutical industry.

Latest Patents

One of his latest patents is for an alkyl or olefinic endcapped polyalkylene oxide solubilizer. This invention provides a method for rendering water-insoluble materials water-soluble, which is particularly useful for solubilizing bioactive materials such as drugs. The method involves forming a non-covalently bonded complex between the drug and a polymer that is soluble in both water and an organic solvent. By combining the medicinal agent with the polymer in an organic solvent, removing the solvent, and dissolving the complex in water or an aqueous buffer, a solid complex that is water-soluble is recovered. Additionally, methods of treatment using these complexes are also provided.

Another significant patent involves human phospholipase activating protein and methods for diagnosing rheumatoid arthritis. This invention outlines methods for detecting elevated levels of phospholipase A₂ activating protein in individuals suspected of having rheumatoid arthritis. The process includes providing a sample of body fluid or tissue, contacting it with a specific antibody, and detecting the antibody to indicate the presence of the protein. Elevated levels of this protein compared to those in healthy individuals can indicate the presence of rheumatoid arthritis.

Career Highlights

Throughout his career, Mike A Clark has worked with various companies, including Enzon, Inc. His innovative work has led to advancements in both drug solubilization and diagnostic methods, showcasing his expertise and dedication to improving healthcare solutions.

Collaborations

Mike has collaborated with notable individuals in his field, including Robert G Shorr and Richard B Greenwald. These partnerships have contributed to the development and success of his inventions.

Conclusion

Mike A Clark is a distinguished inventor whose work in solubilization and medical diagnostics has made a significant impact. His innovative patents and collaborations reflect his commitment to advancing healthcare technologies.