Company Filing History:
Years Active: 1999-2003
Title: Michele Rollence: Innovator in Multivalent Antigen-Binding Proteins
Introduction
Michele Rollence, an accomplished inventor based in Damascus, MD, has significantly contributed to the field of biotechnology with her innovative discoveries. With a total of five patents to her name, Michele's work focuses on the development and production of multivalent antigen-binding proteins.
Latest Patents
Michele's latest patents delve into compositions and genetic constructions coding for multivalent antigen-binding proteins. These patents describe methods for purifying compositions that include both monomeric and multivalent forms of single polypeptide chain molecules. Notably, the production of multivalent proteins may occur via a concentration-dependent association of monomeric proteins or through the rearrangement of regions that involves dissociation followed by reassociation. Michele's inventions also include the formulation of bivalent proteins—comprising both homobivalent and heterobivalent proteins—alongside genetic sequences coding for bivalent single-chain antigen-binding proteins. The applications of her work encompass uses suitable for both monoclonal and polyclonal antibodies, including the development of bispecific antigen-binding molecules.
Career Highlights
Michele Rollence is currently associated with Enzon, Inc., where she leverages her expertise to push the boundaries of scientific innovation. Her patents not only display her inventiveness but also highlight her commitment to advancing pharmaceutical development. The impact of her work is felt across various medical applications, making significant strides in therapeutic methodologies.
Collaborations
Throughout her career, Michele has collaborated with remarkable colleagues such as Marc D. Whitlow and James F. Wood. These partnerships have fostered a rich environment of innovation, allowing for the cross-pollination of ideas and expertise that enrich the research and development landscape.
Conclusion
Michele Rollence stands out as an influential inventor in the realm of biotechnology, particularly in the production of multivalent antigen-binding proteins. With her five patents, Michele not only reflects her creativity but also her dedication to enhancing medical science. Her work has far-reaching implications for therapeutic development, highlighting the importance of innovation in the healthcare industry.