Company Filing History:
1 out of 832,843 Years Active: 2009
Title: Michele Cramer: Innovator in Biosensor Technology
Introduction
Michele Cramer is an accomplished inventor based in Baltimore, MD (US). He has made significant contributions to the field of biosensor technology, particularly in the measurement of zinc ions. His innovative approach has led to advancements that enhance the sensitivity and selectivity of biosensors.
Latest Patents
Michele Cramer holds a patent for an "Excitation ratiometric fluorescent biosensor for zinc ion at picomolar levels." This invention presents a highly selective and sensitive method for measuring zinc ions using a carbonic anhydrase-based approach. The technique utilizes an excitation ratiometric format based on resonance energy transfer, allowing for the transduction of zinc ion levels as the ratio of fluorescence intensities excited at two different wavelengths. The method demonstrates a detection limit of approximately 10 pM in zinc-buffered systems, achieving a ten to one thousand-fold improvement over traditional Fura indicators, which also respond to calcium and magnesium. Furthermore, it offers a one hundred thousand-fold enhancement compared to the recently described FuraZin-1.
Career Highlights
Throughout his career, Michele Cramer has focused on developing innovative biosensing technologies. His work has been instrumental in advancing the capabilities of fluorescence microscopy formats for detecting zinc ions at extremely low concentrations. His dedication to research and development has positioned him as a key figure in the field.
Collaborations
Michele has collaborated with notable colleagues, including Richard B. Thompson and Carol Ann Fierke. These partnerships have fostered a collaborative environment that enhances the research and development of biosensor technologies.
Conclusion
Michele Cramer is a pioneering inventor whose work in biosensor technology has significantly impacted the measurement of zinc ions. His innovative patent showcases his commitment to advancing scientific research and improving detection methods.