Michele C Kieke

Michele C Kieke is a prominent inventor based in Urbana, IL (US), known for her significant contributions to the field of biotechnology. With a total of 6 patents, she has made remarkable advancements in the genetic methods of tethering polypeptides to yeast cell walls, which have important implications for protein binding and selection.

Latest Patents

One of her latest patents, titled "Yeast cell surface display of proteins and uses thereof," presents a genetic method for tethering polypeptides to the yeast cell wall in a form that is accessible for binding to macromolecules. This innovative approach, when combined with fluorescence-activated cell sorting, allows for the selection of proteins with altered affinity, specificity, or conditional binding. The patent also describes methods for genetic fusion of polypeptides to the yeast Aga2p cell wall protein, enabling the display of multiple protein agglutinins on the yeast surface. This technology effectively mimics the cell surface display of antibodies, facilitating affinity maturation in vivo and providing a means to isolate T cell receptor mutants for enhanced binding affinity and specificity.

Career Highlights

Michele C Kieke is affiliated with the University of Illinois, where she continues to push the boundaries of research in her field. Her work has garnered attention for its potential applications in immunology and therapeutic development.

Collaborations

Michele has collaborated with notable researchers such as K Dane Wittrup and David M Kranz, further enhancing the impact of her work through shared expertise and innovative ideas.

Conclusion

Michele C Kieke's contributions to yeast cell surface display technologies exemplify her role as a leading inventor in biotechnology. Her innovative patents and collaborative efforts continue to advance the field and hold promise for future applications.

Profile summary based on public USPTO records.