Company Filing History:
Years Active: 2001-2015
Title: Michele C Kieke: Innovator in Yeast Cell Surface Display Technologies
Introduction
Michele C Kieke is a prominent inventor based in Urbana, IL (US), known for her significant contributions to the field of biotechnology. With a total of 6 patents, she has made remarkable advancements in the genetic methods of tethering polypeptides to yeast cell walls, which have important implications for protein binding and selection.
Latest Patents
One of her latest patents, titled "Yeast cell surface display of proteins and uses thereof," presents a genetic method for tethering polypeptides to the yeast cell wall in a form that is accessible for binding to macromolecules. This innovative approach, when combined with fluorescence-activated cell sorting, allows for the selection of proteins with altered affinity, specificity, or conditional binding. The patent also describes methods for genetic fusion of polypeptides to the yeast Aga2p cell wall protein, enabling the display of multiple protein agglutinins on the yeast surface. This technology effectively mimics the cell surface display of antibodies, facilitating affinity maturation in vivo and providing a means to isolate T cell receptor mutants for enhanced binding affinity and specificity.
Career Highlights
Michele C Kieke is affiliated with the University of Illinois, where she continues to push the boundaries of research in her field. Her work has garnered attention for its potential applications in immunology and therapeutic development.
Collaborations
Michele has collaborated with notable researchers such as K Dane Wittrup and David M Kranz, further enhancing the impact of her work through shared expertise and innovative ideas.
Conclusion
Michele C Kieke's contributions to yeast cell surface display technologies exemplify her role as a leading inventor in biotechnology. Her innovative patents and collaborative efforts continue to advance the field and hold promise for future applications.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.