Michel H Klein

Title: Innovations of Michel H Klein

Introduction

Michel H Klein is a notable inventor based in Willowdale, CA. He has made significant contributions to the field of biotechnology, particularly in the development of immunogenic compositions and diagnostic applications.

Latest Patents

Klein holds 5 patents, with his latest invention focusing on an analog of Haemophilus influenzae Hin47 with reduced protease activity. This isolated and purified analog exhibits decreased protease activity, less than about 10% of that of the natural Hin47 protein, while maintaining similar immunogenic properties. The invention includes a nucleic acid molecule encoding the Hin47 analog, which can be introduced into a cell to produce the analog. The resulting immunogenic compositions can be formulated as vaccines for in vivo administration, providing protection against diseases caused by bacterial pathogens, including Haemophilus species. Additionally, the Hin47 analog and its encoding nucleic acid have potential applications in diagnostics.

Career Highlights

Throughout his career, Michel H Klein has focused on innovations that enhance vaccine development and diagnostic methods. His work has contributed to advancements in the understanding of bacterial pathogens and their interactions with the immune system.

Collaborations

Klein has collaborated with notable colleagues, including Sheena M Loosmore and Yan-Ping Yang, to further his research and development efforts.

Conclusion

Michel H Klein's innovative work in biotechnology, particularly in the development of immunogenic compositions, showcases his commitment to advancing medical science and improving public health. His contributions continue to have a significant impact on the field.