Company Filing History:
2 out of 131 
2 out of 75 
2 out of 920 
Years Active: 1998-2005
Title: Michael Willis: Innovator in Nucleic Acid Ligand Complexes
Introduction
Michael Willis is a notable inventor based in Louisville, Colorado. He has made significant contributions to the field of biotechnology, particularly in the development of nucleic acid ligand complexes. With a total of 6 patents to his name, Willis has demonstrated a commitment to advancing medical science through innovative solutions.
Latest Patents
One of his latest patents focuses on vascular endothelial growth factor (VEGF) nucleic acid ligand complexes. This invention discloses a method for preparing a complex comprised of a VEGF Nucleic Acid Ligand and a Non-Immunogenic, High Molecular Weight Compound or Lipophilic Compound. The process involves identifying a VEGF Nucleic Acid Ligand using SELEX methodology and associating it with a suitable compound. Additionally, the invention includes complexes that comprise one or more VEGF Nucleic Acid Ligands in association with these compounds, as well as a lipid construct that incorporates a VEGF Nucleic Acid Ligand or complex.
Another significant patent by Willis involves the systematic evolution of ligands by exponential enrichment, specifically through the photoselection of nucleic acid ligands. This method provides techniques to obtain nucleic acid ligands that photocrosslink to target molecules associated with disease states. The process includes contacting a candidate mixture of photocrosslinkable nucleic acids with a biological substance from a disease state, forming nucleic acid-target molecule complexes, and subsequently irradiating these complexes to create crosslinked structures.
Career Highlights
Throughout his career, Michael Willis has worked with prominent companies in the pharmaceutical and biotechnology sectors. Notable organizations include Nexstar Pharmaceuticals, Inc. and Somalogic, Incorporated. His work in these companies has contributed to the advancement of innovative medical solutions.
Collaborations
Willis has collaborated with esteemed colleagues in his field, including Larry M. Gold and Tad H. Koch. These partnerships have further enriched his research and development efforts.
Conclusion
Michael Willis stands out as an influential inventor in the realm of nucleic acid ligand complexes. His innovative patents and collaborations reflect his dedication to improving medical science and technology.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.