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For the Inventor, By the Inventor

Malvern, PA, United States of America

Michael W Winkley

USPTO Granted Patents = 20

Average Co-Inventor Count = 1.9

ph-index = 3

Forward Citations = 40(Granted Patents)


Location History:

  • Malvern, PA (US) (1976 - 1990)
  • St. Albans, VT (US) (1992 - 1996)

Company Filing History:

goldMedal20 out of 1,567 
 
American Home Products Corporation
 patents

Years Active: 1976-1996

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20 patents (USPTO):Explore Patents
1. 5523427 - Medrogestone production (1996-06-04),
2. 5519153 - Medrogestone production (1996-05-21),
3. 5428151 - Medrogestrone production (1995-06-27),
4. 5149700 - Substituted arylsulfonamides and benzamides (1992-09-22),
5. 4935515 - 2,3,4,5-tetrahyd (1990-06-19),
6. 4882323 - 1,2,3,4,5,6-hexahydro[1,3,6]triazocino[1,1-a]benzimidazoles (1989-11-21),
7. 4801706 - N-substituted-hexahydro-1,2,5-triazepines (1989-01-31),
8. 4785118 - Process for preparing indoline-2-carboxylic acids via (1988-11-15),
9. 4755505 - 1-[2-(dialkyl (1988-07-05),
10. 4727183 - Process for the asymmetric synthesis of chiral (1988-02-23),
11. 4645857 - Process for preparing indoline-2-carboxylic acids via (1987-02-24),
12. 4644081 - Process for the asymmetric synthesis of chiral indoline-2-carboxylic (1987-02-17),
13. 4614806 - Process for the asymmetric synthesis of chiral indoline-2-carboxylic (1986-09-30),
14. 4585879 - Process for preparing indoline-2-carboxylic acids via (1986-04-29),
15. 4438031 - N-(Alkylsulfonyl)-L-proline amide and N-(alkylsulfonyl)-2-carboxylic (1984-03-20),

Title: Michael W. Winkley: Innovator in Medrogestone Production

Introduction

Michael W. Winkley, a distinguished inventor based in Malvern, Pennsylvania, has made significant contributions to the field of pharmaceuticals through his innovative work on medrogestone production. With a remarkable portfolio of 20 patents, Winkley has established himself as a leading figure in the development of specialized chemical processes.

Latest Patents

Among his latest patents, Winkley has introduced groundbreaking methods for the production of medrogestone, specifically focusing on the solvate 3.beta., 5.alpha., 6.beta.-trihydroxy-6.alpha., 17.alpha.-dimethylpregnan-20-one monomethanolate. His inventive process involves the production of this crystalline intermediate through solvent displacement with methanol in a solution of the crucial precursor compound. Additionally, he developed a comprehensive process for producing 6,17.alpha.-dimethylpregna-4,6-diene-3,20-dione by isolating the aforementioned monomethanolate from a Grignard reaction product and subsequently transforming it into the desired final product through a series of oxidation and dehydration steps.

Career Highlights

Michael W. Winkley currently works at American Home Products Corporation, where he has played an integral role in the advancement of pharmaceutical development. His expertise in organic chemistry and innovative production techniques has garnered recognition within the industry, further emphasizing the impact of his patents.

Collaborations

Throughout his career, Winkley has collaborated with esteemed colleagues such as Ronald J. McCaully and Gerhard R. Wendt. These partnerships have strengthened his research endeavors, leading to the successful development and patenting of new pharmaceutical processes.

Conclusion

Michael W. Winkley's commitment to innovation and excellence in the pharmaceutical field has resulted in valuable contributions that enhance the production of essential medications. With a strong foundation of patents and collaborative efforts, he continues to shape the future of pharmaceutical development through his pioneering work in medrogestone production.

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