Location History:
- Wesley Chapel, FL (US) (2011)
- Santa Clara, CA (US) (2013)
Company Filing History:
Years Active: 2011-2013
Title: Innovations in Drug Delivery: The Contributions of Michael VanAuker
Introduction
Michael VanAuker is an accomplished inventor based in Santa Clara, CA. He has made significant contributions to the field of drug delivery systems, particularly through his innovative work with nonionic surfactant vesicles known as niosomes. With a total of 2 patents, his research focuses on enhancing targeted drug delivery and imaging techniques.
Latest Patents
One of VanAuker's latest patents is centered on the ultrasound enhancement of drug release across non-ionic surfactant membranes. This method utilizes niosomes in combination with ultrasound to facilitate targeted drug delivery and imaging. Niosomes are capable of encapsulating therapeutic agents and enhancing their uptake by physiological membranes. The innovative approach allows for non-invasive delivery by altering the niosome membrane structure using ultrasound.
In his research, niosomes composed of polyoxyethylene sorbitan monostearate (Tween 61), cholesterol, and dicetyl phosphate were synthesized through a thin film hydration technique. Carboxyfluorescein dye (CF) served as a model drug to demonstrate the delivery process. The study monitored the amount of dye in the niosomes, the concentration of the vesicles, and their mean particle size after each 5-minute incremental exposure to ultrasound. The findings revealed that ultrasound at specific frequencies can reversibly permeabilize the lipid membrane of niosomes, allowing for controlled release of compounds without compromising the niosome structure.
Career Highlights
Michael VanAuker is affiliated with the University of South Florida, where he continues to advance research in drug delivery systems. His work has garnered attention for its potential applications in medical therapies and imaging techniques.
Collaborations
Throughout his career, VanAuker has collaborated with notable colleagues, including Elizabeth Hood and Joel A Strom. These partnerships have contributed to the development and refinement of his innovative research.
Conclusion
Michael VanAuker's contributions to the field of drug delivery through his innovative use of niosomes and ultrasound technology highlight the importance of research in enhancing therapeutic applications. His work continues to pave the way for advancements in targeted drug delivery systems.