Michael Thomas Bethune

Title: Innovations of Michael Thomas Bethune

Introduction

Michael Thomas Bethune is an accomplished inventor based in Castro Valley, CA (US). He has made significant contributions to the field of biotechnology, particularly in the development of chimeric antigen receptors (CARs) for cancer treatment. With a total of 2 patents, his work focuses on enhancing the efficacy and safety of CAR T cell therapies.

Latest Patents

One of his latest patents is the "Protease-activating CD45-gate CAR." This invention features a reversibly gated effector polypeptide that includes an extracellular CD45 recruiting domain, a protease-cleavable linker, and a polypeptide with an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain. The patent also covers nucleic acids, including vectors and expression vectors that encode the CAR, as well as immune cells such as T cells that express these nucleic acids. The methods of treatment outlined in this patent involve administering these engineered cells to treat various forms of cancer, utilizing CAR T cell therapy.

Another significant patent is focused on "Chimeric antigen receptors with enhanced signaling and activities." This invention provides recombinant antigen receptors that include modified cytoplasmic domains for improved signaling, thereby enhancing performance and safety. The patent also details methods for engineering immune cells to express these recombinant antigen receptors, which can be used to treat a variety of conditions, including blood cancers and solid tumors.

Career Highlights

Throughout his career, Michael has worked with notable companies such as Allogene Therapeutics, Inc. and Pfizer Corporation. His experience in these leading organizations has contributed to his expertise in the field of immunotherapy and biotechnology.

Collaborations

Michael has collaborated with esteemed colleagues, including Yi Zhang and Thomas John Van Blarcom. These partnerships have further enriched his research and development efforts in the field of CAR technology.

Conclusion

Michael Thomas Bethune is a pioneering inventor whose work in CAR technology is paving the way for innovative cancer treatments. His patents reflect a commitment to advancing medical science and improving patient outcomes.