This inventor holds 1 USPTO granted patent and 4 published patent applications and 2 EPO patents. Top assignees: Indiana University, The Jackson Laboratory. Active years: 2024.
Company Filing History:
1 out of 804 
1 out of 96 
Years Active: 2024
Title: Michael Sasner: Innovator in Alzheimer's Research
Introduction
Michael Sasner is a notable inventor based in Bar Harbor, ME (US). He has made significant contributions to the field of Alzheimer's research through his innovative work in genetic engineering. His research focuses on developing genetically modified mice that can help in understanding and treating Alzheimer's disease.
Latest Patents
Michael Sasner holds a patent for a genetically modified mouse expressing human APOE4 and mouse Trem2 p.R47H. This patent describes genetically modified mice characterized by symptoms associated with the expression of human APOE4 and mouse Trem2, which are relevant to non-familial late-onset Alzheimer's disease. The genome of the mouse includes a DNA sequence encoding a human APOE4 protein operably linked to a promoter, as well as a DNA sequence encoding a mouse Trem2 protein with a mutation p.R47H, also operably linked to a promoter. These modifications allow the mouse to express both human APOE4 and mouse Trem2, providing a valuable model for screening compounds for the treatment of Alzheimer's disease.
Career Highlights
Throughout his career, Michael Sasner has worked with prestigious institutions, including The Jackson Laboratory and Indiana University. His work at these organizations has allowed him to collaborate with leading scientists and contribute to groundbreaking research in genetics and neurodegenerative diseases.
Collaborations
Michael has collaborated with Gregory Carter, enhancing the research efforts in the field of Alzheimer's disease. Their combined expertise has led to advancements in understanding the genetic factors involved in this complex condition.
Conclusion
Michael Sasner's innovative work in developing genetically modified mice has the potential to significantly impact Alzheimer's research and treatment. His contributions to the field highlight the importance of genetic engineering in understanding complex diseases.