This inventor holds 3 USPTO granted patents. Top assignees: California Institute of Technology, Hitachi Chemical Research Center, Inc.. Active years: 1996-1999.
Company Filing History:
2 out of 4,624 
1 out of 38 Years Active: 1996-1999
Title: Michael S. Waterman: Innovator in Sequence Information Signal Processing
Introduction
Michael S. Waterman is a prominent inventor known for his contributions to the field of sequence information signal processing. Based in Culver City, CA, he holds a total of 3 patents that showcase his innovative approach to comparing genetic sequences and enhancing computational efficiency in biological research.
Latest Patents
One of Waterman's latest patents is the "Sequence Information Signal Processor." This electronic circuit is designed to compare two sequences, such as genetic sequences, to determine which alignment produces the greatest similarity. The circuit features a linear array of series-connected processors, each storing a single element from one sequence and comparing it with successive elements from the other sequence. The processor generates a scoring parameter that indicates the segment producing the highest degree of similarity. This scoring parameter is then used to facilitate further comparisons, ultimately determining the alignment with the highest value.
Another significant patent is the "Sequence Information Signal Processor for Local and Global String." This integrated circuit chip performs high-speed calculations based on a dynamic programming algorithm defined by Waterman and Smith. It serves as a building block for a linear systolic array, allowing for increased performance by connecting additional chips. The chip is designed using CMOS VLSI technology, providing the equivalent of about 400,000 transistors. It can handle sequences as long as 4,194,304 elements without external software, and it allows for variable similarity measures across processors.
Career Highlights
Throughout his career, Waterman has worked with esteemed institutions such as the California Institute of Technology and Hitachi Chemical Research Center, Inc. His work has significantly advanced the field of computational biology, particularly in the analysis of DNA and protein sequences.
Collaborations
Waterman has collaborated with notable individuals in his field, including John C. Peterson and Timothy J. Hunkapillar. These collaborations have contributed to the development of innovative technologies in sequence processing.
Conclusion
Michael S. Waterman is a key figure in the realm of sequence information signal processing, with patents that reflect his innovative spirit and dedication to advancing technology in biological research. His contributions continue to influence the field and pave the way for future advancements.