Location History:
- Boulder, CO (US) (2006 - 2008)
- Hamburg, DE (2007 - 2012)
Company Filing History:
Years Active: 2006-2012
Title: Michael Leuck: Innovator in Oligonucleotide Synthesis
Introduction
Michael Leuck is a prominent inventor based in Hamburg, Germany. He has made significant contributions to the field of oligonucleotide synthesis, holding a total of six patents. His innovative methods have advanced the quality and efficiency of synthetic oligonucleotides.
Latest Patents
Leuck's latest patents include a process for the synthesis of oligonucleotides. This invention discloses novel methods for synthesizing oligonucleotides with nucleoside phosphoramidites on solid supports. The methods involve stepwise chain assembly on supports with 5'-acyl phosphoramidites. The synthesis cycles consist of a front-end deprotection step, a phosphoramidite coupling step, a phosphite oxidation step, and an optional capping step. These methods improve the quality of synthetic oligonucleotides by preventing the formation of deletion sequences and avoiding acidic reagents that can lead to depurination side products. Additionally, he has developed novel nucleoside phosphoramidite compositions that carry acyl front-end protective groups cleavable with primary amines or phenolates. Another patent focuses on novel activators for oligonucleotide and phosphoramidite synthesis, utilizing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups as highly efficient activators.
Career Highlights
Michael Leuck is currently associated with Sigma-Aldrich Co. LLC, where he continues to innovate in the field of oligonucleotide synthesis. His work has been instrumental in enhancing the methodologies used in this area, contributing to advancements in biochemistry and molecular biology.
Collaborations
Leuck has collaborated with notable colleagues, including Andreas Wolter and Wolfgang A Pieken. These collaborations have further enriched his research and development efforts in oligonucleotide synthesis.
Conclusion
Michael Leuck's contributions to the field of oligonucleotide synthesis through his innovative patents and collaborations have significantly impacted the scientific community. His work continues to pave the way for advancements in molecular biology and biochemistry.