Company Filing History:
Years Active: 1994-1998
Title: Innovations in Cardiac Surgery: The Contributions of Michael L Hess
Introduction
Michael L Hess is an accomplished inventor based in Midlothian, VA (US). He has made significant contributions to the field of cardiac surgery, particularly through his innovative research and patents. With a total of 2 patents, his work focuses on improving outcomes in cardiac procedures.
Latest Patents
One of Michael L Hess's latest patents is titled "Histidine as a protective agent in cardiac surgery and myocardial." This invention has been found to be efficacious in preventing ischemic/reperfusion induced myocardial injury both functionally and ultrastructurally. In his experiments, isolated perfused rat hearts were subjected to 30 minutes of global ischemia and 20 minutes of reperfusion. Histidine concentrations ranging from 10 to 50 mM were administered throughout the experiment. The results showed that during ischemia and reperfusion without histidine, the contractile function and coronary flow were 59±10% and 78±6% of control, respectively. However, perfusion with histidine (25 mM and above) resulted in significant increases in contractility (94±4%) and coronary flow (92±4%). The incidence of arrhythmias during reperfusion was 100 percent in the ischemic/reperfused group, with an average duration of 13.23±4.48 minutes. The addition of 25 mM histidine significantly reduced the incidence and duration of arrhythmias. The protective effects of histidine were found to be significantly better than those of SOD/catalase/mannitol. Furthermore, histidine has been shown to significantly reduce infarct size and the occurrence of arrhythmias in vivo.
Career Highlights
Michael L Hess has worked with notable organizations such as Cytos Pharmaceuticals LLC and Virginia Commonwealth University. His research has contributed to advancements in cardiac care and has the potential to improve patient outcomes significantly.
Collaborations
Michael has collaborated with Rakesh C Kukreja, further enhancing the impact of his research in the field of cardiac surgery.
Conclusion
Michael L Hess's innovative work in cardiac surgery, particularly through his patent on histidine as a protective agent, showcases his dedication to improving medical outcomes. His contributions are vital in the ongoing quest for advancements in cardiac care.