Kent, WA, United States of America

Michael L Diegel


Average Co-Inventor Count = 6.0

ph-index = 3

Forward Citations = 56(Granted Patents)


Company Filing History:


Years Active: 1998-2002

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3 patents (USPTO):Explore Patents

Title: The Innovations of Michael L. Diegel in HIV-1 Research

Introduction

Michael L. Diegel, a prominent inventor based in Kent, WA, has made significant contributions to the field of biotechnology and medicine. With a total of three patents to his name, his groundbreaking work primarily focuses on the development of monoclonal antibodies aimed at inhibiting the production of HIV-1 retrovirus.

Latest Patents

Diegel's latest patents include advanced methods for inhibiting the production of HIV-1 retrovirus using monoclonal antibodies targeting the CD2 antigen. These innovations describe an anti-CD2 monoclonal antibody that can take various forms, such as a chimeric nonclonal antibody CD2 SFv-Ig. This antibody can be produced through the expression of specific constructs cloned in recombinant cultures. The antibody can compete effectively with CD2 SFv-Ig for binding to the CD2 antigen, showcasing at least an 80% effectiveness on a molar basis. Additionally, these monoclonal antibodies have significant potential for therapeutic applications, including the modulation of interactions between T lymphocytes and monocytes, ultimately leading to the potential inhibition of HIV-1 production in infected patients.

Career Highlights

Michael L. Diegel is currently affiliated with Bristol-Myers Squibb Company, a leading global biopharmaceutical firm. His work at the company emphasizes innovative approaches to addressing chronic diseases and aims to improve the quality of life for patients worldwide.

Collaborations

Throughout his career, Diegel has collaborated with accomplished colleagues, including Lisa K. Gilliland and Patricia A. Moran. These partnerships have fostered a vibrant exchange of ideas, further enhancing his research and the development of effective treatments.

Conclusion

Michael L. Diegel stands as a notable figure in the realm of biomedical innovation, particularly in the fight against HIV-1. His patents reflect a deep commitment to advancing medical science, and his collaborative efforts underscore the importance of teamwork in achieving transformative results in healthcare. His ongoing work promises to yield significant advancements in the treatment of HIV and related illnesses.

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