Company Filing History:
Years Active: 1995-1999
Title: Michael Joseph McLean: Innovator in Oligonucleotide Synthesis
Introduction
Michael Joseph McLean is a notable inventor based in Nantwich, GB. He has made significant contributions to the field of chemistry, particularly in the development of compounds suitable for oligonucleotide synthesis. With a total of 4 patents to his name, McLean's work has advanced the understanding and application of homocyclic and heterocyclic compounds.
Latest Patents
McLean's latest patents focus on innovative methods and compounds for oligonucleotide synthesis. One of his key patents describes a support carrying a homocyclic or heterocyclic ring containing a first and second carbon atom. In this invention, the first carbon atom is substituted by a nucleophilic group or a group convertible to a nucleophilic group upon treatment with base. The second carbon atom is substituted by a hydroxy group, a hydroxy group protected by an acid-labile protecting group, or a phosphate group substituted by an oligonucleotide. Importantly, the first and second carbon atoms are directly connected by a covalent bond, making this compound suitable for use in oligonucleotide synthesis. The patent also details methods for its preparation and use, along with novel compounds for attachment to the support.
Career Highlights
Michael McLean is currently associated with Zeneca Limited, where he continues to innovate in the field of chemical compounds. His work has been instrumental in advancing techniques that are crucial for the synthesis of oligonucleotides, which have applications in various areas of biotechnology and pharmaceuticals.
Collaborations
Throughout his career, McLean has collaborated with notable colleagues, including Andrew John Garman and David Holland. These collaborations have fostered a productive environment for innovation and research.
Conclusion
Michael Joseph McLean's contributions to the field of oligonucleotide synthesis through his patents and collaborations highlight his role as a significant inventor. His work continues to influence advancements in chemical research and applications.
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