This inventor holds 7 USPTO granted patents and 5 published patent applications, plus 1 CIPO patent and 2 EPO patents. Top assignees: Meiragtx UK Ii Limited, Meiragtx Gene Regulation Limited. Active years: 2019-2026.
Company Filing History:
Years Active: 2019-2026
Title: The Innovative Contributions of Michael J Volles
Introduction
Michael J Volles is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of gene regulation, holding a total of 7 patents. His work focuses on innovative methods for regulating gene expression, which have potential applications in various biotechnological fields.
Latest Patents
One of his latest patents is titled "Regulation of gene expression by aptamer-mediated modulation of alternative splicing." This invention provides a platform and methods for regulating the expression of a target gene using exposure to an aptamer ligand, such as a small molecule. The platform features a polynucleotide gene regulation cassette that is integrated into the target gene, including a synthetic riboswitch positioned within a 5' intron-alternative exon-3′ intron. The riboswitch consists of an effector region and a sensor region, allowing for the alternative exon to be spliced into the target gene mRNA when the ligand is absent, thus preventing expression of the target gene. Conversely, when the ligand is present, the alternative exon is not spliced, enabling expression of the target gene.
Another notable patent is "Regulation of gene expression via aptamer-mediated control of self-cleaving ribozymes." This invention provides polynucleotide constructs for regulating gene expression through aptamer-based modulation of self-cleaving ribozymes. It includes methods for using these constructs to control gene expression in response to the presence or absence of a ligand that binds the aptamer. The invention also outlines methods for creating riboswitches that can either decrease or increase target gene expression based on the presence of an aptamer ligand.
Career Highlights
Throughout his career, Michael J Volles has worked with several notable companies, including MeiraGTx UK Limited and MeiraGTx Gene Regulation Limited. His work in these organizations has contributed to advancements in gene therapy and regulation technologies.
Collaborations
Michael has collaborated with esteemed colleagues such as Olivier F Danos and Xuecui Guo, further enhancing the impact of his research and innovations in the field.
Conclusion
Michael J Volles is a distinguished inventor whose work in gene regulation has led to significant advancements in biotechnology. His innovative patents and collaborations continue to influence the landscape of genetic research and applications.