Michael H Smith

Title: Michael H. Smith: Innovator in RNA Formulations

Introduction

Michael H. Smith is a prominent inventor based in Needham, MA (US). He has made significant contributions to the field of biotechnology, particularly in the development of RNA formulations. With a total of 2 patents, his work focuses on improving lipid-based compositions for delivering nucleic acids and proteins in vivo.

Latest Patents

Smith's latest patents include innovative approaches to RNA formulations. The first patent discloses improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use for delivering agents in vivo. This advancement is crucial for the effective delivery of nucleic acids and proteins. The second patent outlines methods for preparing particles and related compositions, which may include polynucleotides such as mRNA. This method emphasizes the importance of altering properties like surface charge and pH to enhance yield and prevent fouling during the filtration process.

Career Highlights

Michael H. Smith is currently associated with Modernatx, Inc., where he continues to push the boundaries of innovation in biotechnology. His work has been instrumental in advancing the understanding and application of RNA delivery systems.

Collaborations

Smith collaborates with notable colleagues, including Stephen G. Hoge and Joseph Schariter, who contribute to the innovative environment at Modernatx, Inc. Their combined expertise fosters a culture of creativity and scientific advancement.

Conclusion

Michael H. Smith's contributions to RNA formulations and lipid-based compositions highlight his role as a leading inventor in biotechnology. His patents reflect a commitment to improving the delivery of critical biological agents, paving the way for future innovations in the field.