Location History:
- Guleph, CA (2013)
- Guelph, CA (2002 - 2023)
Company Filing History:
2 out of 108 
2 out of 2 
1 out of 832,961 Years Active: 2002-2023
Title: Michael D McLean: Innovator in Plant Biotechnology
Introduction
Michael D McLean is a prominent inventor based in Guelph, Canada. He has made significant contributions to the field of plant biotechnology, particularly in enhancing recombinant protein expression in plants. With a total of 5 patents, his work has paved the way for advancements in agricultural biotechnology.
Latest Patents
One of McLean's latest patents focuses on the transient silencing of ARGONAUTE1 and ARGONAUTE4 to increase recombinant protein expression in plants. This invention provides a plant or plant cell with reduced endogenous AGO1 and AGO4 expression compared to a wild-type plant or plant cell. In this embodiment, the plant or plant cell further comprises a nucleic acid sequence encoding a recombinant protein, resulting in increased expression of the recombinant protein compared to a wild-type counterpart. Additionally, he has developed methods for reducing aglycosylation of recombinant proteins produced in plants. Another notable patent involves a transgenic plant with reduced fucosyltransferase and xylosyltransferase activity, which ensures that less than 10% of the total glycan on a protein produced by the plant is α1,3-fucosylated, and less than 3% is β1,2-xylosylated.
Career Highlights
Throughout his career, McLean has worked with esteemed organizations such as the University of Guelph and Plantform Corporation. His research has significantly impacted the field of plant biotechnology, leading to innovative solutions for protein production in plants.
Collaborations
McLean has collaborated with notable colleagues, including J Christopher Hall and Gabrielle Richard. These partnerships have further enhanced his research and contributions to the field.
Conclusion
Michael D McLean is a distinguished inventor whose work in plant biotechnology has led to important advancements in recombinant protein expression. His innovative patents and collaborations continue to influence the agricultural biotechnology landscape.