University of Guelph

Plantform Corporation

Other

Michael D McLean

Gabrielle Richard

J Christopher Hall

Robert G Korneluk

Joh-E Ikeda

Natalie Roy

Mani S Mahadevan

Alex E MacKenzie

Kiva Ferraro

Michael Marit

Zacharie LeBlanc

Kurt C Almquist

Christopher J Hall

Xuemei Xie

Nina Weisser

A plant or plant cell with reduced endogenous AGO1 and AGO4 expression compared to a wild-type plant or plant cell is provided. In one embodiment, the plant or plant cell further comprises a nucleic acid sequence encoding a recombinant protein and the plant or plant cell has increased expression of the recombinant protein compared to a wild-type plant or plant cell comprising the nucleic acid sequence. Methods of reducing aglycosylation of recombinant protein produced in plants are also provided.

Transient silencing of ARGONAUTE1 and ARGONAUTE4 to increase recombinant protein expression in plants

A genetically modified plant or plant cell with reduced &#x3b1;1,3-fucosyltransferase and &#x3b2;1,2-xylosyltransferase activity compared to a wild type plant or plant cell, wherein less than 10% of the total glycan on a protein produced by the plant or plant cell is &#x3b1;1,3-fucosylated glycan and less than 3% of the total glycan on the protein is &#x3b2;1,2-xylosylated glycan is provided. In one embodiment, the plant or plant cell comprises three T-DNA insertions expressing five copies of RNAi targeting &#x3b1;1,3-fucosyltranserase and three copies of RNAi targeting &#x3b2;1,2xylosyltransferase.

Transgenic plant with reduced fucosyltransferase and xylosyltransferase activity

A method of constructing a VH library from an immunized camelid, using whole venom or an extract thereof. There is also provided VH antibody fragments isolated from a library produced in hyperimmunized llama. These VH antibody fragments were sequenced, and specifically bind &#x3b1;-cobratoxin.

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A method of constructing a VH library from an immunized camelid, using whole venom or an extract thereof There is also provided VH antibody fragments isolated from a library produced in hyperimmunized llama These VH antibody fragments were sequenced, and specifically bind &#x3b1;-cobratoxin.

The gene for autosomal recessive neurodegenerative disorder Spinal Muscular Atrophy has been mapped to a region of chromosome 5. The gene encodes a protein having homology with apoptosis inhibitor proteins of viruses so that the encoded protein has been labelled as a neuronal apoptosis inhibitor protein (NAIP). A deletion in the (NAIP) domain was identified in persons with Type I, II and III Spinal Muscular Atrophy (SMA) and not in the normal non-SMA population.

Neuronal apoptosis inhibitor protein gene sequence and mutations causative of spinal muscular atrophy

Growing community of inventors

Guelph, Canada

Michael D McLean