Michael C Rice

Title: Michael C Rice: Innovator in Genomic Technologies

Introduction

Michael C Rice is a prominent inventor based in Newtown, PA (US), known for his significant contributions to the field of genomic technologies. With a total of nine patents to his name, he has developed innovative methods that enhance the detection and separation of polymorphisms, as well as targeted chromosomal genomic alterations.

Latest Patents

Among his latest patents is a method for polymorphism detection and separation. This invention allows for multiplexing and can be adapted to various existing detection systems, enabling target amplification without the need for PCR. The methods facilitate the selective isolation of allelic variants, which is particularly useful in constructing coisogenic cell collections that differ genotypically by single nucleotide changes at defined loci. Another notable patent involves targeted chromosomal genomic alterations using modified single-stranded oligonucleotides. These oligonucleotides feature at least one modified nuclease-resistant terminal region, which includes phosphorothioate linkages, LNA analogs, or 2'-O-Me base analogs.

Career Highlights

Michael has worked at the University of Delaware, where he has contributed to various research initiatives. His work has been instrumental in advancing the understanding of genomic alterations and their applications in biotechnology.

Collaborations

Throughout his career, Michael has collaborated with notable individuals such as Eric B Kmiec and Howard Gamper. These partnerships have further enriched his research and innovation efforts.

Conclusion

Michael C Rice stands out as a key figure in the realm of genomic technologies, with a strong portfolio of patents that reflect his innovative spirit and dedication to advancing science. His contributions continue to influence the field and pave the way for future discoveries.