This inventor holds 3 USPTO granted patents. Top assignees: Dartmouth College, University of Massachusetts. Active years: 1997-2009.
Location History:
- Grafton, MA (US) (1997 - 1999)
- Golden, CO (US) (2009)
Company Filing History:
3 out of 701 
3 out of 1,623 
Years Active: 1997-2009
Title: Michael C Appel: Innovator in T-Cell Tolerance and Transplantation
Introduction
Michael C Appel is a notable inventor based in Grafton, MA (US). He has made significant contributions to the field of immunology, particularly in methods for inducing T-cell tolerance in transplant recipients. With a total of 3 patents, his work has the potential to impact organ transplantation and diabetes treatment.
Latest Patents
Michael C Appel's latest patents focus on innovative methods for inducing T-cell non-responsiveness using anti-gp39 antibodies. These methods involve administering allogeneic or xenogeneic cells that express donor antigens, along with an antagonist that inhibits the interaction of a receptor on recipient T cells. This approach aims to induce T-cell tolerance to various transplants, including liver, kidney, heart, lung, skin, muscle, neuronal tissue, stomach, and intestine. Additionally, he has developed methods for treating diabetes by administering allogeneic or xenogeneic cells expressing donor antigens, a gp39 antagonist, and pancreatic islets.
Career Highlights
Throughout his career, Michael C Appel has worked with prestigious institutions such as Dartmouth College and the University of Massachusetts. His research has contributed to advancements in transplant immunology and therapeutic strategies for autoimmune diseases.
Collaborations
Michael has collaborated with esteemed colleagues, including Randolph J Noelle and Fiona H Durie. Their combined expertise has furthered the understanding of T-cell biology and transplantation.
Conclusion
Michael C Appel's innovative work in T-cell tolerance and transplantation showcases his dedication to advancing medical science. His contributions have the potential to improve the outcomes of organ transplants and diabetes treatment, making him a significant figure in the field of immunology.