Michael B Roof

Title: **Michael B Roof: Innovator in Virology and Protein Engineering**

Introduction

Michael B Roof, based in Ames, IA, is a prominent inventor known for his significant contributions to the field of virology and protein engineering. With a remarkable portfolio of 38 patents, Roof stands out for his innovative approaches in developing diagnostic tools and methods for vaccine quantification.

Latest Patents

Among his latest patents is the invention of polypeptides useful for detecting anti-rhabdovirus antibodies. This innovative concept focuses on recombinantly constructed proteins that are essential for analytical assays. These proteins aid in determining the presence of antibodies specific to rhabdovirus in biological samples. The patent includes a unique polypeptide involving an ectodomain of a rhabdovirus glycoprotein linked to a heterologous multimerization domain, presenting exciting possibilities for enhanced diagnostic methodologies.

Another significant patent from Roof relates to the quantification of vaccine compositions. This invention outlines methods and mass-labeled peptides critical for measuring viral proteins in samples containing agents that bind to these viral proteins. Utilizing mass-spectroscopic analyses, the invention provides standards with known amounts of labeled and unlabeled signature peptides, particularly for antigens in vaccines for porcine circovirus.

Career Highlights

Michael B Roof has made remarkable strides in his career, with key positions at reputable organizations such as Boehringer Ingelheim Vetmedica GmbH. His work has been pivotal in advancing the development of vaccines and diagnostic tools, showcasing the impact of his inventions in the veterinary and medical sectors.

Collaborations

Throughout his career, Roof has collaborated with notable professionals, including Marc Allan Eichmeyer and Eric Martin Vaughn. These partnerships have fostered innovation and the successful advancement of several pioneering projects, underscoring the importance of teamwork in the complex field of research and development.

Conclusion

Michael B Roof is a distinguished inventor whose work has significantly advanced the fields of virology and protein engineering. With an impressive array of patents, his contributions not only help in the detection of viral infections but also enhance the efficacy of vaccine composition analysis. As he continues to innovate, Roof remains a vital figure in the realms of science and technology, demonstrating the profound impact one inventor can have on public health and safety.