Company Filing History:
Years Active: 1989
Title: The Innovative Contributions of Michael A. Good
Introduction
Michael A. Good is a notable inventor based in Rockville, MD (US). He has made significant contributions to the field of immunology, particularly in the development of vaccines against malaria. His work focuses on the circumsporozoite (CS) protein of Plasmodium falciparum, which is crucial for creating effective anti-sporozoite malarial vaccines.
Latest Patents
Michael A. Good holds a patent for a malarial immunogen. This patent details the analysis of the CS protein to develop a new anti-sporozoite malarial vaccine. The localization of T-cell recognition sites on this molecule is essential for vaccine design. By employing an algorithm to predict T-cell sites and utilizing a large panel of H-2 congenic mice, a major nonrepetitive T-cell site was identified. When a synthetic peptide corresponding to this site was covalently linked to the major B-cell site on the molecule, an immunogen capable of eliciting a high titer antibody response was created. This peptide sequence can prime helper T-cells for a secondary response to the intact CS protein. This site represents the first helper T-cell site described for the CS molecule outside of the repetitive region and is a major immunodominant T-site on the molecule. The approach outlined in this patent is beneficial for the rational design and construction of more efficacious vaccines.
Career Highlights
Michael A. Good is associated with the United States of America as represented by the Department of Health. His work has been instrumental in advancing the understanding of malaria and developing potential vaccines to combat this disease. His innovative research has contributed to the scientific community's efforts to address global health challenges.
Collaborations
Michael A. Good has collaborated with notable scientists such as Jay A. Berzofsky and Louis H. Miller. These collaborations have further enhanced the research and development of effective vaccines against malaria.
Conclusion
Michael A. Good's contributions to the field of immunology, particularly in malaria vaccine development, highlight his innovative spirit and dedication to improving public health. His patent on the malarial immunogen represents a significant step forward in vaccine research.