Location History:
- Boston, MA (US) (1998)
- Jamaica Plain, MA (US) (1992 - 2004)
- Plain, MA (US) (2007)
Company Filing History:
12 out of 1,373 
7 out of 850 
1 out of 3,221 
Years Active: 1992-2007
Title: **Michael A Gimbrone, Jr: Innovative Contributions to Cardiovascular Science**
Introduction
Michael A Gimbrone, Jr. is a prominent figure in the field of cardiovascular research, based in Jamaica Plain, MA. With a remarkable portfolio of 19 patents, Gimbrone has made significant contributions to our understanding of arterial and venous biology, particularly in the context of angiogenesis and cardiovascular disease.
Latest Patents
Among his latest innovations, Gimbrone has focused on the development of artery smooth muscle- and vein smooth muscle-specific proteins. His research highlights the molecular distinctions between arterial and venous cells, revealing crucial mechanisms during the earliest stages of angiogenesis to adulthood. One of his key patents addresses the role of EphrinB2, a ligand expressed on arterial cells, and its receptor EphB4 found on venous cells. This work emphasizes how targeted disruption of the EphrinB2 gene can prevent the necessary remodeling of veins and arteries, demonstrating the reciprocal relationships vital for proper vascular formation.
Moreover, his inventions extend to compositions and methods for treating and diagnosing cardiovascular diseases, identifying differentially expressed genes in various disease states. His patents provide innovative approaches for monitoring patient responses and developing therapeutic interventions for conditions such as atherosclerosis, hypertension, and arterial inflammation.
Career Highlights
Michael A Gimbrone, Jr. has had a noteworthy career, holding key positions at reputable institutions. He has been associated with Brigham and Women's Hospital, Inc. and Millennium Pharmaceuticals Limited, where he has played a pivotal role in advancing cardiovascular research and biotechnology.
Collaborations
Throughout his career, Gimbrone has collaborated with distinguished colleagues, including Dean A Falb and Michael P Bevilacqua. These partnerships have contributed to a greater depth of knowledge and innovation in cardiovascular science.
Conclusion
In summary, Michael A Gimbrone, Jr.'s work has greatly impacted the field of cardiovascular research, exemplified by his numerous patents and collaborations. His continued efforts in uncovering the complexities of vascular biology pave the way for future advancements in medical treatments and diagnostics.