Location History:
- Palo Alto, CA (US) (1990)
- Boston, MA (US) (1996 - 2007)
Company Filing History:
8 out of 1,036 
2 out of 5,307 
1 out of 902 
Years Active: 1990-2007
Title: Merton Bernfield: Innovator in Synthetic Constructs
Introduction
Merton Bernfield is a notable inventor based in Boston, MA (US). He has made significant contributions to the field of synthetic constructs, particularly in the area of proteoglycans. With a total of 9 patents to his name, Bernfield's work has had a profound impact on biomedical research.
Latest Patents
Among his latest patents is the construction and use of synthetic constructs encoding syndecan. This invention involves a purified mammalian proteoglycan and genetic information encoding such proteoglycans. The constructs have a core polypeptide molecular weight of about 30 kD to about 35 kD. They comprise a hydrophilic amino terminal extracellular region, a hydrophilic carboxy terminal cytoplasmic region, and a transmembrane hydrophobic region. Additionally, the constructs feature a protease-susceptible cleavage sequence and at least one glycosylation site for the attachment of a heparan sulfate chain. The glycosylation site is represented by a specific formula, which includes an amino acid residue with an acidic sidechain.
Career Highlights
Merton Bernfield has worked with prestigious organizations such as Children's Medical Center Corporation and Leland Stanford Junior University. His career has been marked by a commitment to advancing the understanding of proteoglycans and their applications in medicine.
Collaborations
Throughout his career, Bernfield has collaborated with notable individuals, including Scott Saunders and Masato Kato. These collaborations have contributed to the development of innovative solutions in his field.
Conclusion
Merton Bernfield's contributions to the field of synthetic constructs and proteoglycans highlight his role as a leading inventor. His work continues to influence biomedical research and innovation.