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For the Inventor, By the Inventor

Charlestown, MA, United States of America

Megan Sykes

This inventor holds 20 USPTO granted patents, primarily in Transplantation Biology. Top assignees: The General Hospital Corporation, Columbia University, Genetics Institute, Inc.. Active years: 1996-2022.

IDiyas Innovation Intelligence. (2026). Inventor Profile: Megan Sykes. Retrieved from https://idiyas.com/inventor/megan-sykes

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

USPTO Granted Patents = 20

% Patents Active = 75.0

Average Co-Inventor Count = 1.4

ph-index = 10

Forward Citations = 300(Granted Patents)


Location History:

  • Charlestown, MA (US) (1996 - 2009)
  • Boston, MA (US) (1997 - 2011)
  • Bronx, NY (US) (2018)
  • New York, NY (US) (2022)

Company Filing History:

goldMedal19 out of 3,073 
 
The General Hospital Corporation
 patents
silverMedal2 out of 2,554 
 
Columbia University
 patents
bronzeMedal2 out of 392 
 
Genetics Institute, Inc.
 patents
where one patent can have more than one assignee

Years Active: 1996-2022

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Areas of Expertise:
Xenotransplantation
T-Cell Generation
Hematologic Disorders
Mixed Chimerism
Costimulatory Blockade
Allografting
Graft Versus Host Disease
Induced Tolerance
Interleukin-12
Xenograft Thymus
Procyte Interleukin-10
20 patents (USPTO):Explore Patents
1. 11284607 - Genetic modification of pigs for xenotransplantation (2022-03-29),
2. 10023840 - Generation of autologous T-cells in mice (2018-07-17),
3. 7939062 - Methods for human allografting (2011-05-10),
4. 7892578 - Treatment of hematologic disorders (2011-02-22),
5. 7638121 - Methods for human allografting (2009-12-29),
6. 7498023 - Blockade of T cell migration into epithelial GVHD target tissues as an approach to achieving anti-tumor effects against lymphohematopoietic malignancies without GVHD (2009-03-03),
7. 7408039 - Kits for treatment of hematologic disorders (2008-08-05),
8. 7332157 - Methods for human allografting (2008-02-19),
9. 6877514 - Mixed chimerism and tolerance (2005-04-12),
10. 6718986 - Mixed chimerism and tolerance (2004-04-13),
11. 6558662 - Treatment of hematologic disorders (2003-05-06),
12. 6514513 - Costimulatory blockade and mixed chimerism in transplantation (2003-02-04),
13. 6412492 - Mixed chimerism and tolerance (2002-07-02),
14. 6296846 - Induced tolerance to xenografts (2001-10-02),
15. 6280957 - Costimulatory blockade and mixed chimerism in allo-transplantation (2001-08-28),

Title: Innovations in Genetic Modification by Megan Sykes

Introduction

Megan Sykes, based in Charlestown, MA, has made significant contributions to the field of biomedical engineering through her innovative inventions. With an impressive portfolio of 20 patents, she is renowned for her pioneering work in genetic modification and xenotransplantation.

Latest Patents

Megan Sykes holds several groundbreaking patents, including her recent inventions focused on genetic modification of pigs for xenotransplantation. This invention includes the use of transgenic donor animals designed to enhance the long-term survival of their cells, tissues, and organs when transplanted into human patients. By utilizing a 'genetic switch', the transgenic animals maintain their health while simultaneously optimizing the expression of human transgenes for improved transplant tolerance.

Another notable patent is focused on the generation of autologous T-cells in mice. This invention offers a novel animal model and methods for producing large quantities of diverse and functional naive T cells, which are derived from the bone marrow of adult donors. These developments are crucial in advancing research and therapy in immunology and transplantation.

Career Highlights

Throughout her career, Megan Sykes has been associated with leading organizations, including The General Hospital Corporation and Genetics Institute, Inc. This experience has bolstered her expertise in biomedical research and enhanced her reputation as a leader in genetic modification.

Collaborations

Megan has collaborated with other prominent researchers such as Thomas R. Spitzer and David H. Sachs. These collaborations have contributed to her innovative approaches and have led to significant advancements in the fields of transplantation and immunology.

Conclusion

Megan Sykes continues to push the boundaries of science with her significant patents and collaborations. Her work not only enhances our understanding of genetic modification and xenotransplantation but also paves the way for more effective treatments in the future.

Profile summary based on public USPTO records.
Data Sources: USPTO Patent Grant XML, Patent Center, EPO & CIPO • Normalized by IDiyas Innovation Graph. Methodology & provenance architecturePlease report any incorrect information to [email protected]
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