Megan M Barber

Title: Megan M Barber: Innovator in Target Binding Molecules

Introduction

Megan M Barber is a notable inventor based in Parrish, FL (US). She has made significant contributions to the field of molecular biology, particularly in the development of target binding molecules. With a total of 2 patents, her work has implications for pharmaceutical formulations and therapeutic applications.

Latest Patents

One of her latest patents is titled "Target binding molecules identified by kinetic target-guided synthesis." This patent outlines methods for identifying target binding molecules that can bind to proteins or nucleic acids. The methods involve mixing two or more fragments capable of forming the target binding molecule with the target itself. This innovative approach can identify molecules that bind to shallow binding pockets on the surface of targets, such as the Bcl-XL and Mcl-1 proteins from the Bcl-2 family. Additionally, she has developed new acyl sulfonamides that bind to these proteins using thio acid and sulfonyl azide fragments through sulfo-click chemistry. Another patent describes quinazoline-based compounds and their formulations, which can be effective in inhibiting and killing specific targets. The methods also include treating subjects in need of these compounds.

Career Highlights

Megan has worked with esteemed institutions such as the University of South Florida and the Penn State Research Foundation. Her research has contributed to advancements in molecular synthesis and therapeutic applications.

Collaborations

Megan has collaborated with notable colleagues, including Roman Manetsch and David Lawrence Flanigan. Their combined expertise has furthered the development of innovative solutions in the field.

Conclusion

Megan M Barber's contributions to the field of molecular biology and her innovative patents highlight her role as a leading inventor. Her work continues to influence the development of new therapeutic strategies and compounds.