This inventor holds 1 USPTO granted patent and 1 published patent application. Top assignee: San Diego State University Research Foundation. Active years: 2025.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
Years Active: 2025
Title: Innovations in Fluorescence Imaging by Mckenzie Wyllie
Introduction
Mckenzie Wyllie is an accomplished inventor based in San Diego, California. She has made significant contributions to the field of fluorescence imaging and spectroscopy through her innovative research. Her work focuses on developing new compounds that enhance the capabilities of nucleic acid detection.
Latest Patents
Wyllie's most notable patent is for pyrimidine nucleoside compounds designed for fluorescence imaging and spectroscopy. This patent addresses the limitations of existing fluorescent nucleobase surrogates, which have been inadequate for single-molecule detection due to their limited brightness and short absorption and emission wavelengths. Wyllie synthesized a new tricyclic pyrimidine nucleoside analogue with a push-pull conjugated system. The resulting compound, C-linked 8-(diethylamino)benzo[b][1,8]naphthyridin-2(1H)-one nucleoside (ABN), exhibits remarkable properties, including an extinction coefficient of 20,000 M^-1cm^-1 and a quantum yield that increases when base paired with adenine in duplex DNA oligonucleotides. This new fluorescent nucleobase analogue is the brightest and most red-shifted known, providing robust single-molecule fluorescence detection capabilities.
Career Highlights
Mckenzie Wyllie is affiliated with the San Diego State University Foundation, where she continues her research and development efforts. Her work has garnered attention for its potential applications in various fields, including molecular biology and medical diagnostics.
Collaborations
Wyllie has collaborated with notable colleagues, including Byron W. Purse and George Samaan. These collaborations have further enriched her research and contributed to the advancement of fluorescence imaging technologies.
Conclusion
Mckenzie Wyllie's innovative work in developing new fluorescent nucleobase compounds has the potential to revolutionize the field of fluorescence imaging and spectroscopy. Her contributions are paving the way for more effective nucleic acid detection methods, which could have significant implications in scientific research and medical diagnostics.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile