Company Filing History:
Years Active: 2006-2008
Title: Max J Paape: Innovating Bovine Health Solutions
Introduction
Max J Paape, based in Silver Spring, MD, is a distinguished inventor known for his innovative contributions to bovine health. With a total of four patents under his name, Paape has made significant strides in understanding and enhancing the health of bovine mammary cells.
Latest Patents
One of Paape's latest patents focuses on a method for sensitizing bovine mammary cells to respond to LPS. His research has demonstrated that the membrane CD14 (mCD14) on the cell surface of monocytes, macrophages, and PMN mediates the activation of these cells by LPS. Moreover, his work with soluble CD14 (sCD14) has revealed its role in binding to LPS, effectively blocking it from binding to mCD14. In his investigatory studies, he cloned and expressed a recombinant bovine soluble CD14 polypeptide (rbosCD14) using a baculovirus expression system. The findings highlighted that rbosCD14 inhibited LPS-induced increases in CD18 expression and TNFα mRNA in vitro, ultimately reducing mortality in LPS-injected mice. Additionally, rbosCD14 sensitized mammary epithelial cells to low concentrations of LPS, resulting in the recruitment of white blood cells and the prevention of LPS-induced infections.
Career Highlights
Paape works with the United States of America, as represented by the Secretary of Agriculture. His focus on bovine health and disease prevention has positioned him as a leading figure in agricultural research and innovation. His contributions not only further scientific understanding but also enhance the health and productivity of livestock.
Collaborations
Throughout his career, Max J Paape has collaborated with noteworthy colleagues such as Yan Wang and Dante S Zarlenga. These partnerships have amplified the impact of his research, leading to advancements in veterinary medicine and livestock management.
Conclusion
Max J Paape remains a pivotal figure in the field of agricultural innovation, with his groundbreaking patents addressing critical challenges in bovine health. His ongoing research and collaborative efforts continue to shape the future of livestock health and productivity, providing valuable insights and solutions for the agricultural sector.